Ion exchangers mediating NaCl transport in the renal proximal tubule

  title={Ion exchangers mediating NaCl transport in the renal proximal tubule},
  author={P. Aronson},
  journal={Cell Biochemistry and Biophysics},
  • P. Aronson
  • Published 2007
  • Medicine, Biology
  • Cell Biochemistry and Biophysics
  • We have studied the mechanisms of NaCl transport in the mammalian proximal tubule. Studies of isolated brush-border membrane vesicles confirmed the presence of Na+−H+ exchange and identified Cl−-formate and Cl−-oxalate exchangers as possible mechanisms of uphill Cl− entry. We found that formate and oxalate each stimulate NaCl absorption in microperfused proximal tubules. Stimulation of NaCl absorption by formate was blocked by the Na+−H+-exchange inhibitor EIPA, whereas stimulation by oxalate… CONTINUE READING
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