Ion exchange chromatographic separation and isolation of oligosaccharides of intact low-molecular-weight heparin for the determination of their anticoagulant and anti-inflammatory properties.

@article{Shastri2013IonEC,
  title={Ion exchange chromatographic separation and isolation of oligosaccharides of intact low-molecular-weight heparin for the determination of their anticoagulant and anti-inflammatory properties.},
  author={Madhur D. Shastri and C. R. Johns and Joseph P Hutchinson and Manish M Khandagale and Rahul P. Patel},
  journal={Analytical and bioanalytical chemistry},
  year={2013},
  volume={405 18},
  pages={6043-52}
}
It is well known that enoxaparin, a widely used anticoagulant and low-molecular-weight heparin containing a large number of oligosaccharides, possesses anti-inflammatory activity. Whilst enoxaparin has shown promising results in various inflammatory disorders, some of its oligosaccharides have anti-inflammatory properties and others increase the risk of bleeding due to their anticoagulant effects. The aim of this study was to develop an effective ion exchange chromatographic (IC) technique… CONTINUE READING