Ion channels regulating mast cell biology

  title={Ion channels regulating mast cell biology},
  author={Ian Ashmole and Peter Bradding},
  journal={Clinical \& Experimental Allergy},
  pages={491 - 503}
Mast cells play a central role in the pathophysiology of asthma and related allergic conditions. Mast cell activation leads to the degranulation of preformed mediators such as histamine and the secretion of newly synthesised proinflammatory mediators such as leukotrienes and cytokines. Excess release of these mediators contributes to allergic disease states. An influx of extracellular Ca2+ is essential for mast cell mediator release. From the Ca2+ channels that mediate this influx, to the K… 
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