Ion-channels on parasite muscle: pharmacology and physiology

@article{Robertson2007IonchannelsOP,
  title={Ion-channels on parasite muscle: pharmacology and physiology},
  author={Alan P Robertson and Richard John Martin},
  journal={Invertebrate Neuroscience},
  year={2007},
  volume={7},
  pages={209-217}
}
Ion-channels are essential components of excitable cells. This fact has been exploited in the development of anthelmintic agents; the majority of which act on nematode ion channels. The purpose of this review is to describe the site of action of some frequently used anthelmintic compounds: nAChRs and levamisole/pyrantel; Glu-Cls and avermectins/mylbemycins; GABA receptors and piperazine. Also described is some of the physiological and pharmacological data on other nematode muscle ion-channels… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS

Insects in anthelminthics research: Lady beetle-derived harmonine affects survival, reproduction and stem cell proliferation of Schistosoma mansoni

Josina Kellershohn, Laura Thomas, +5 authors Simone Haeberlein
  • PLoS neglected tropical diseases
  • 2019

Menthol acts as a positive allosteric modulator on nematode levamisole sensitive nicotinic acetylcholine receptors

  • International journal for parasitology. Drugs and drug resistance
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

Suppression of Schistosoma japonicum Acetylcholinesterase Affects Parasite Growth and Development

  • International journal of molecular sciences
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 69 REFERENCES

A Cl channel selectively conducts dicarboxylic products from glucose metabolism and indicates a role in transmembrane transport of waste organic anions

MA Valkanov, RJ Martin
  • J Membr Biol
  • 1995
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Valkanov MA (1995) A chloride channel in isolated

RJ Martin
  • 1995
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

c-Aminobutyric acid- and piperazine-activated single channel currents from Ascaris suum body muscle

RJ Martin
  • Pharmacol
  • 1985
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

A chloride channel in isolated muscle vesicles from Ascaris suum conducts products of anaerobic metabolism , suggesting a role in excretion of organicanions

RJ Martin, MA Valkanov
  • J Physiol
  • 1995
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL

Control of neglected tropical diseases.

  • The New England journal of medicine
  • 2007
VIEW 1 EXCERPT

The nematode neuropeptide , AF 2 ( KHEYLRFNH 2 ) , increases voltageactivated calcium currents in Ascaris suum muscle

AJ Wolstenholme, AT Rogers
  • Br J Pharmacol
  • 2007