Ion channels of N-terminally linked alamethicin dimers: enhancement of cation-selectivity by substitution of Glu for Gln at position 7.

Abstract

Alamethicin forms voltage-gated ion channels that have moderate cation-selectivity. The enhancement of the cation-selectivity by introducing negatively charged residues at positions 7 and 18 has been studied using the tethered homodimers of alamethicin with Q7 and E18 (di-alm-Q7E18) and its analog with E7 and Q18 (di-alm-E7Q18). In the dimeric peptides… (More)

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@article{Okazaki2007IonCO, title={Ion channels of N-terminally linked alamethicin dimers: enhancement of cation-selectivity by substitution of Glu for Gln at position 7.}, author={Takashi Okazaki and Yasuo Nagaoka and Koji Asami}, journal={Bioelectrochemistry}, year={2007}, volume={70 2}, pages={380-6} }