Ion channels and transporters in cancer. 3. Ion channels in the tumor cell-microenvironment cross talk.

@article{Arcangeli2011IonCA,
  title={Ion channels and transporters in cancer. 3. Ion channels in the tumor cell-microenvironment cross talk.},
  author={Annarosa Arcangeli},
  journal={American journal of physiology. Cell physiology},
  year={2011},
  volume={301 4},
  pages={C762-71}
}
The traditional view of cancer as a collection of proliferating cells must be reconsidered, and cancer must be viewed as a "tissue" constituted by both transformed cells and a heterogeneous microenvironment, that tumor cells construct and remodel during multistep tumorigenesis. The "tumor microenvironment" (TM) is formed by mesenchymal, endothelial, and immune cells immersed in a network of extracellular matrix (ECM) proteins and soluble factors. The TM strongly contributes to tumor progression… CONTINUE READING

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