Ion channels: Gate expectations

@article{Garcia2004IonCG,
  title={Ion channels: Gate expectations},
  author={Maria L. Garcia},
  journal={Nature},
  year={2004},
  volume={430},
  pages={153-155}
}
The opening and closing — gating — of ion channels in response to specific stimuli is crucial for cell function. The membrane-partitioning activities of two venom toxins give insights into the mechanisms involved. 

The gramicidin ion channel: a model membrane protein.

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Effect of graded hydration on the dynamics of an ion channel peptide: a fluorescence approach.

The results show that tryptophans in gramicidin, present in the single-stranded beta6.3 conformation, experience slow solvent relaxation giving rise to red-edge excitation shift (REES), and it is concluded that REES could prove to be a potentially sensitive tool to explore the dynamics of proteins under conditions of changing hydration.

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