Ion channelopathies of the immune system.

  title={Ion channelopathies of the immune system.},
  author={Martin Vaeth and Stefan Feske},
  journal={Current opinion in immunology},
Ion channels and transporters move ions across membrane barriers and are essential for a host of cell functions in many organs. They conduct K+, Na+ and Cl-, which are essential for regulating the membrane potential, H+ to control intracellular and extracellular pH and divalent cations such as Ca2+, Mg2+ and Zn2+, which function as second messengers and cofactors for many proteins. Inherited channelopathies due to mutations in ion channels or their accessory proteins cause a variety of diseases… CONTINUE READING