Ion channelopathies of the immune system.

@article{Vaeth2018IonCO,
  title={Ion channelopathies of the immune system.},
  author={Martin Vaeth and Stefan Feske},
  journal={Current opinion in immunology},
  year={2018},
  volume={52},
  pages={
          39-50
        }
}
Ion channels and transporters move ions across membrane barriers and are essential for a host of cell functions in many organs. They conduct K+, Na+ and Cl-, which are essential for regulating the membrane potential, H+ to control intracellular and extracellular pH and divalent cations such as Ca2+, Mg2+ and Zn2+, which function as second messengers and cofactors for many proteins. Inherited channelopathies due to mutations in ion channels or their accessory proteins cause a variety of diseases… CONTINUE READING
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