Ion channel structure: Emerging structure of the Nicotinic Acetylcholine receptors

@article{Karlin2002IonCS,
  title={Ion channel structure: Emerging structure of the Nicotinic Acetylcholine receptors},
  author={A. Karlin},
  journal={Nature Reviews Neuroscience},
  year={2002},
  volume={3},
  pages={102-114}
}
The conversion of acetylcholine binding into ion conduction across the membrane is becoming more clearly understood in terms of the structure of the receptor and its transitions. A high-resolution structure of a protein that is homologous to the extracellular domain of the receptor has revealed the binding sites and subunit interfaces in great detail. Although the structures of the membrane and cytoplasmic domains are less well determined, the channel lining and the determinants of selectivity… CONTINUE READING
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