Ion channel involvement in the acute vascular effects of thiazide diuretics and related compounds.

@article{Calder1993IonCI,
  title={Ion channel involvement in the acute vascular effects of thiazide diuretics and related compounds.},
  author={Julie A. Calder and M. D. Pinhas Schachter and P. S. Sever},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={265 3},
  pages={1175-80}
}
The involvement of calcium and potassium channels in mediating the vascular actions of hydrochlorothiazide, indapamide and cicletanine were investigated in guinea pig small vessels mounted on the Mulvany myograph. Hydrochlorothiazide (10 microM) and cicletanine (10 microM) were weak calcium antagonists shifting the calcium dose-response curve half a log… CONTINUE READING