Ion channel involvement in hypoxia-induced spreading depression in hippocampal slices

@article{Aitken1991IonCI,
  title={Ion channel involvement in hypoxia-induced spreading depression in hippocampal slices},
  author={Peter G. Aitken and Jian Jing and J. Young and G. G. Somjen},
  journal={Brain Research},
  year={1991},
  volume={541},
  pages={7-11}
}
Rat hippocampal tissue slices were made hypoxic in control medium and in medium containing the ion channel blockers tetraethylammonium (TEA), 4-aminopyridine (4-AP), or tetrodotoxin (TTX). Postsynaptic evoked potentials, extracellular DC potential Vec, and in some experiments extracellular potassium concentration [K+]o were monitored in stratum pyramidale of the CA1 region. TEA (10 mM) decreased the latency of hypoxia-induced spreading depression (SD), and reduced the amplitudes of the changes… CONTINUE READING

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