Ion channel clustering by membrane-associated guanylate kinases. Differential regulation by N-terminal lipid and metal binding motifs.

@article{ElHusseini2000IonCC,
  title={Ion channel clustering by membrane-associated guanylate kinases. Differential regulation by N-terminal lipid and metal binding motifs.},
  author={Alaa El-Din El-Husseini and J. Rick Topinka and Joshua Eli Lehrer-Graiwer and Bonnie L Firestein and Sarah E. Craven and Chiye J Aoki and David S. Bredt},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 31},
  pages={
          23904-10
        }
}
The postsynaptic density protein PSD-95 and related membrane-associated guanylate kinase (MAGUK) proteins assemble signal transduction complexes at sites of cell-cell contact including synapses. Whereas PSD-95 and PSD-93 occur only at postsynaptic sites in hippocampal neurons, SAP-102 also occurs in axons. In heterologous cells, PSD-95 and PSD-93 mediate cell surface ion channel clustering, but SAP-102 and SAP-97 do not. This selective ion channel clustering activity by MAGUKs is explained by… CONTINUE READING
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