Ion binding constants for gramicidin a obtained from water permeability measurements

@article{Wang1995IonBC,
  title={Ion binding constants for gramicidin a obtained from water permeability measurements},
  author={Kongjiang Wang and Shruti Tripathi and Stephen Hladky},
  journal={The Journal of Membrane Biology},
  year={1995},
  volume={143},
  pages={247-257}
}
Gramicidin A pores are permeable to water and small monovalent cations. For K, Rb, and Cs there is good evidence from conductances and permeability ratios that a second ion can enter a pore already occupied by another, but for Na this evidence is inconclusive and comparison of tracer fluxes and single channel conductances suggests that second ion entries are prohibited. Partly as a result of the complications of second ion entry there have been widely differing estimates for the dissociation… CONTINUE READING