Ion Permeation and Block of P2X2 Purinoceptors: Single Channel Recordings

  title={Ion Permeation and Block of P2X2 Purinoceptors: Single Channel Recordings},
  author={Shuwen Ding and Frederick Sachs},
  journal={The Journal of Membrane Biology},
P2X2 purinoceptors are cation-selective channels activated by ATP and its analogues. Using single channel measurements we studied the channel's selectivity for the alkali metal ions and organic monovalent cations NMDG+, Tris+, TMA+, and TEA+. The selectivity sequence for currents carried by alkali metal ions is: K+ > Rb+ > Cs+ > Na+ > Li+, which is Eisenman sequence IV. This is different from the mobility sequence of the ions in free solution suggesting there is weak interaction between the… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 26 extracted citations


Publications referenced by this paper.
Showing 1-10 of 43 references

Calcium permeability

  • C. Virginio, A. Surprenant, R. A. North
  • 1998
Highly Influential
6 Excerpts

Neuronal P 2 X transmitter - gated cation channels changed their ion selectivity in seconds

  • B. S. Khakh, R. BaoX., C. Labarca, H. A. Lester
  • Nature Neurosci .
  • 1999
Highly Influential
2 Excerpts

Similar Papers

Loading similar papers…