Ion Permeation and Block of P2X2 Purinoceptors: Single Channel Recordings

@article{Ding1999IonPA,
  title={Ion Permeation and Block of P2X2 Purinoceptors: Single Channel Recordings},
  author={Shuwen Ding and Frederick Sachs},
  journal={The Journal of Membrane Biology},
  year={1999},
  volume={172},
  pages={215-223}
}
P2X2 purinoceptors are cation-selective channels activated by ATP and its analogues. Using single channel measurements we studied the channel's selectivity for the alkali metal ions and organic monovalent cations NMDG+, Tris+, TMA+, and TEA+. The selectivity sequence for currents carried by alkali metal ions is: K+ > Rb+ > Cs+ > Na+ > Li+, which is Eisenman sequence IV. This is different from the mobility sequence of the ions in free solution suggesting there is weak interaction between the… CONTINUE READING

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