Ion Pair Strategy in Solid Lipid Nanoparticles: a Targeted Approach to Improve Epidermal Targeting with Controlled Adapalene Release, Resulting Reduced Skin Irritation

@article{Rodrigues2020IonPS,
  title={Ion Pair Strategy in Solid Lipid Nanoparticles: a Targeted Approach to Improve Epidermal Targeting with Controlled Adapalene Release, Resulting Reduced Skin Irritation},
  author={Linna B. O. Rodrigues and F. A. Lima and Camila P. B. Alves and Elis{\^a}ngela Martins-Santos and M. Aguiar and C. A. Oliveira and R. Or{\^e}fice and L. A. Ferreira and Gisele A. C. Goulart},
  journal={Pharmaceutical Research},
  year={2020},
  volume={37}
}
Adapalene (AD) is one of the main retinoids used in the topical therapy of acne, an extremely common skin disease usually associated with psychological morbidity. However, like other retinoids, AD is frequently associated with skin irritation. To overcome the skin irritation, we proposed the encapsulation of AD in solid lipid nanoparticles (SLNs) using the ion pair strategy. The developed SLN-AD was characterized by high-performance liquid chromatography, differential scanning calorimetry, X… Expand

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