Ion Channels: From Conductance to Structure

  title={Ion Channels: From Conductance to Structure},
  author={Francisco Bezanilla},
In this perspective I tell the story (albeit a clearly abridged version) of how our knowledge of ion conduction through ion channels has evolved from a purely electrical concept to a structural dynamics view of ions interacting with a membrane protein. Our progress in this field has shown steady growth over the years but has also been interspersed with sudden jumps of discovery. These leaps have normally been associated with the introduction of a new technical advance or the development of a… CONTINUE READING
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lation between gating charge displacement and the voltage sensitivity of activation

  • D. Sigg, E. Stefani, F. Bezanilla
  • J. Gen. Physiol
  • 1994
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