Ion-Channel Noise Places Limits on the Miniaturization of the Brain’s Wiring

@article{Faisal2005IonChannelNP,
  title={Ion-Channel Noise Places Limits on the Miniaturization of the Brain’s Wiring},
  author={Ahmed A. Faisal and John A. White and Simon B. Laughlin},
  journal={Current Biology},
  year={2005},
  volume={15},
  pages={1143-1149}
}
The action potential (AP) is transmitted by the concerted action of voltage-gated ion channels. Thermodynamic fluctuations in channel proteins produce probabilistic gating behavior, causing channel noise. Miniaturizing signaling systems increases susceptibility to noise, and with many cortical, cerebellar, and peripheral axons <0.5 mum diameter [1, 2 and 3], channel noise could be significant [4 and 5]. Using biophysical theory and stochastic simulations, we investigated channel-noise limits in… CONTINUE READING
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How reliable is the connectivity in cortical neural networks

  • A. A. S14. Faisal, S. B. Laughlin, J. A. White
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