Ion Channel Formation by Tau Protein: Implications for Alzheimer’s Disease and Tauopathies

@inproceedings{Patel2015IonCF,
  title={Ion Channel Formation by Tau Protein: Implications
for Alzheimer’s Disease and Tauopathies},
  author={Nirav R. Patel and Srinivasan Ramachandran and Rustam Azimov and Bruce L. Kagan and R. Jawahar Lal},
  booktitle={Biochemistry},
  year={2015}
}
Tau is a microtubule associated protein implicated in the pathogenesis of several neurodegenerative diseases. Because of the channel forming properties of other amyloid peptides, we employed planar lipid bilayers and atomic force microscopy to test tau for its ability to form ion permeable channels. Our results demonstrate that tau can form such channels, but only under acidic conditions. The channels formed are remarkably similar to amyloid peptide channels in their appearance, physical and… CONTINUE READING
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