Iodoacetate produces striatal excitotoxic lesions.

  title={Iodoacetate produces striatal excitotoxic lesions.},
  author={Russell Thomas Matthews and Robert Ferrante and Bruce G. Jenkins and Susan E. Browne and Kathrin G{\"o}tz and Susanne Berger and Ian Yen-Hung Chen and Myron Flint Beal},
  journal={Journal of neurochemistry},
  volume={69 1},
Impairment of energy production may play a role in the pathogenesis of Huntington's disease (HD). It was recently shown that huntingtin can bind to and possibly inhibit the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH). We found that intrastriatal administration of the GAPDH inhibitor iodoacetate produces striatal lesions that are significantly attenuated by removal of the corticostriatal glutamatergic input, consistent with an excitotoxic mechanism. The lesions are… CONTINUE READING
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