Iodine in Evolution of Salivary Glands and in Oral Health

@article{Venturi2009IodineIE,
  title={Iodine in Evolution of Salivary Glands and in Oral Health},
  author={Sebastiano Venturi and Mattia Venturi},
  journal={Nutrition and Health},
  year={2009},
  volume={20},
  pages={119 - 134}
}
The authors hypothesize that dietary deficiency or excess of iodine (I) has an important role in oral mucosa and in salivary glands physiology. Salivary glands derived from primitive I-concentrating oral cells, which during embryogenesis, migrate and specialize in secretion of saliva and iodine. Gastro-salivary clearance and secretions of iodides are a considerable part of “gastro-intestinal cycle of iodides”, which constitutes about 23% of iodides pool in the human body. Salivary glands… 

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References

SHOWING 1-10 OF 116 REFERENCES
Role of iodine in evolution and carcinogenesis of thyroid, breast and stomach.
TLDR
It is suggested that iodide might have an ancestral antioxidant function in all iodide-concentrating cells from primitive Algae to more recent Vertebrates.
Iodide, thyroid and stomach carcinogenesis: evolutionary story of a primitive antioxidant?
TLDR
It is hypothesized that since the appearance of primitive Algae and the primitive gastral cavity of Porifera, iodide might have an antioxidant role in iodide-concentrating organs, and particularly in the stomach of the Vertebrates and it has now been confirmed experimentally in Algae by a study carried out by Küpper et al.
Iodide excess exerts oxidative stress in some target tissues of the thyroid hormones.
TLDR
Present data allow us to conclude that the alterations due to iodide excess in thyroid gland, hepatic tissue and in blood are mediated through oxidative stress.
Sodium/iodide-symporter: distribution in different mammals and role in entero-thyroid circulation of iodide.
TLDR
The role of gastric NIS is enigmatic and the need to correlate the presence of both NIS protein by immunocytochemistry and NIS mRNA by in situ hybridization is emphasized is emphasized.
Is Iodine A Gatekeeper of the Integrity of the Mammary Gland?
TLDR
It is proposed that an I2 supplement should be considered as an adjuvant in breast cancer therapy because of its suppressive effect on the development and size of both benign and cancer neoplasias.
Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acids from salivary gland, mammary gland, and gastric mucosa.
TLDR
The results suggest that the capacity to actively transport iodine may be a feature common to several secretory and endocrine tissues, such as parotid gland, mammary gland, and gastric mucosa.
Endocrine control of extrathyroidal peroxidases and iodide metabolism.
The role of the thyroid and adrenal glands on iodide transport and peroxidase-catalyzed formation of iodotyrosines in extrathyroidal tissues such as stomach and submaxillary glands has been
Damaged reproduction: the most important consequence of iodine deficiency.
  • J. Dunn, F. Delange
  • Medicine, Biology
    The Journal of clinical endocrinology and metabolism
  • 2001
TLDR
Of the many consequences of iodine deficiency, damage to reproductive function and to the developing fetus and infant is the most severe and is the focus of this commentary.
Salivary peroxidases
TLDR
The modulation of the salivary peroxidase by various factors and the probable mechanism of the modulation has been described and the possible function of the enzyme in iodine metabolism and in bactericidal action has been discussed.
...
...