Iodine deficiency and development of brain

@article{Sethi2004IodineDA,
  title={Iodine deficiency and development of brain},
  author={Vani Sethi and Umesh Kapil},
  journal={The Indian Journal of Pediatrics},
  year={2004},
  volume={71},
  pages={325-329}
}
  • V. Sethi, U. Kapil
  • Published 1 April 2004
  • Biology, Medicine
  • The Indian Journal of Pediatrics
Iodine is a trace element essential for the synthesis of triodothyronine (T3) and thyroxine (T4). Inadequate intake of iodine leads to insufficient production of these hormones, which play a vital role in the process of early growth and development of most organs, especially the brain. The neurological sequele of iodine deficiency are mediated by thyroid hormone deficiency, varying from minimal brain function to a syndrome of severe intellectual disability. All the basic processes of… 
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29 Citations
Background Citations
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29 Citations

Developmental Iodine Deficiency and Hypothyroidism Reduce Phosphorylation of Calcium/Calmodulin-Dependent Kinase II in the Rat Entorhinal Cortex
TLDR
Iodine deficiency and propylthiouracil treatment through gestation and lactation reduce phosphorylation of CaMKII in the EC of pups, which may contribute to understanding the mechanisms that underlie impairment of learning and memory induced by developmental iodine deficiency and hypothyroidism.
Thyroid hormones states and brain development interactions
Maternal marginal iodine deficiency affects the expression of relative proteins during brain development in rat offspring.
TLDR
Free thyroxine levels in marginal iodine-deficient rats decreased after pregnancy in rats with marginal iodine deficiency, affecting the expression of related proteins in the brain of offspring.
The hypothyroid brain
The thyroid gland is controlled by a feedback system, the hypothalamus-pituitary-thyroid axis, and produces thyroid hormone (TH), which plays a critical role in growth, development and cellular…
Levothyroxine rescues the lead-induced hypothyroidism and impairment of long-term potentiation in hippocampal CA1 region of the developmental rats.
Brain Findings Associated with Iodine Deficiency Identified by Magnetic Resonance Methods: A Systematic Review
TLDR
A review of studies that use MR methods to identify changes on brain volume or other global structural abnormalities and explain the mechanism of ID causing thyroid dysfunction and hence cognitive damage is provided.
Interrelationships of undernutrition and neurotoxicity: food for thought and research attention.
Fluorosis and Iodine Deficiency Disorders in India
TLDR
This review focuses on fluorosis and iodine deficiency disorders, two serious, highly prevalent metabolic disorders that are under-reported and addressed through structured national programmes, but the implementation unfortunately is in a compartmentalized manner.
Facilitating Knowledge of Women on Importance of Iodine in Foetal Brain Development through Nursing Education: An Evidence-Based Educational Intervention
TLDR
It was showed that women did not have enough knowledge regarding the importance of iodine in fetal brain development and evidence-based nursing is one approach that may enable future healthcare providers to manage the explosion of new literature and technology and ultimately may result in improved patient outcomes.
A Study on Renal Function Status of Patients with Hypothyroidism attending a Tertiary Care Hospital in North Bengal
TLDR
The present study attempts to correlate the effects of thyroid hormones on renal functions more precisely in a population with greater risk of developing hypothyroidism, i.e., in Darjeeling District of West Bengal.
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