Iodine-Promoted Semmler-Wolff Reactions: Step-Economic Access to meta-Substituted Primary Anilines via Aromatization.

Abstract

An atom- and step-economic access to an array of unprotected meta-substituted primary anilines was disclosed using the Semmler-Wolff reaction, promoted by molecular iodine. Therein, noble metal catalysts and inert atmosphere are unnecessary while the forcing reaction conditions and the lengthy synthesis can be avoided. The synthetic utility of this approach is evident in the de novo syntheses of three bioactive molecules with good total yields.

DOI: 10.1002/chem.201701712

Cite this paper

@article{Wang2017IodinePromotedSR, title={Iodine-Promoted Semmler-Wolff Reactions: Step-Economic Access to meta-Substituted Primary Anilines via Aromatization.}, author={S Wang and Xia You and Da-Yuan Zhao and Neng-Jie Mou and Qun-Li Luo}, journal={Chemistry}, year={2017}, volume={23 49}, pages={11757-11760} }