Iodine-131-anti-B1 radioimmunotherapy for B-cell lymphoma.

  title={Iodine-131-anti-B1 radioimmunotherapy for B-cell lymphoma.},
  author={Mark S. Kaminski and Kenneth R. Zasadny and Issac R Francis and Matthias Fenner and Charles W. Ross and Adam Milik and Judith Estes and Melissa K Tuck and Denise D Regan and Susan Fisher and Stephan Glenn and Richard L. Wahl},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={14 7},
PURPOSE The CD20 B-lymphocyte surface antigen expressed by B-cell lymphomas is an attractive target for radioimmunotherapy, treatment using radiolabeled antibodies. We conducted a phase I dose-escalation trial to assess the toxicity, tumor targeting, and efficacy of nonmyeloablative doses of an anti-CD20 monoclonal antibody (anti-B1) labeled with iodine-131 (131I) in 34 patients with B-cell lymphoma who had failed chemotherapy. PATIENTS AND METHODS Patients were first given tracelabeled doses… CONTINUE READING
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