Iodine-125-labeled cRGD-gold nanoparticles as tumor-targeted radiosensitizer and imaging agent

  title={Iodine-125-labeled cRGD-gold nanoparticles as tumor-targeted radiosensitizer and imaging agent},
  author={Ning Su and Yajie Dang and Guangli Liang and Guizhi Liu},
  booktitle={Nanoscale research letters},
Research interests on radiosensitive property of gold nanoparticles (GNPs) are rapidly raised because of the extensively proved in vitro effectiveness and clinical necessity. However, the issue of targeted accumulation of GNPs in tumor tissues hindered the transference to in vivo applications. In this study, hybrid nano-sized cyclic Arg-Gly-Asp-conjugated GNPs (cRGD-GNPs) integrated with radioactive iodine-125 was fabricated as tumor-targeted radiosensitizer. Therapeutic effects, including… CONTINUE READING
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