Iodine-124 labelled annexin-V as a potential radiotracer to study apoptosis using positron emission tomography.

@article{Glaser2003Iodine124LA,
  title={Iodine-124 labelled annexin-V as a potential radiotracer to study apoptosis using positron emission tomography.},
  author={Matthias Glaser and David R. Collingridge and Eric Ofori Aboagye and Lisa Bouchier-Hayes and Oliver C. Hutchinson and Stephen J. Martin and Pat Price and Frank B. Brady and Sajinder K. Luthra},
  journal={Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine},
  year={2003},
  volume={58 1},
  pages={
          55-62
        }
}
Annexin-V is a calcium-dependent protein that binds with high affinity to phosphaditylserine exposed during apoptosis. The aim of this study was to radiolabel annexin-V with iodine-124 for use as a potential probe of apoptosis by positron emission tomography. Annexin-V was radioiodinated directly using the cyclotron-produced positron emitter iodine-124 by the chloramine-T (CAT) method and indirectly by the pre-labelled reagent N-succinimidyl 3-[124I]iodobenzoate ([124I]m-SIB). Some reaction… CONTINUE READING
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