Iodinated contrast media differentially affect afferent and efferent arteriolar tone and reactivity in mice: a possible explanation for reduced glomerular filtration rate.

@article{Liu2012IodinatedCM,
  title={Iodinated contrast media differentially affect afferent and efferent arteriolar tone and reactivity in mice: a possible explanation for reduced glomerular filtration rate.},
  author={Zhi Zhao Liu and Vin{\'i}cius U. Viegas and Andrea Perlewitz and En Yin Lai and Pontus Persson and Andreas Patzak and Mauricio M Sendeski},
  journal={Radiology},
  year={2012},
  volume={265 3},
  pages={762-71}
}
PURPOSE To determine the effect of the iodinated contrast medium iodixanol on arteriolar tone in afferent and efferent arterioles of the glomerulus and the functional interactions with the major modulators of arteriolar tone, angiotensin II and nitric oxide, in mice. MATERIALS AND METHODS Animal handling conformed to the ethics guidelines of the Office for Health and Social Matters of Berlin. Arterioles were isolated from 136 C57BL/6 mice, perfused with either vehicle solution or iodixanol… CONTINUE READING
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