Iodinated contrast media cause endothelial damage leading to vasoconstriction of human and rat vasa recta.

@article{Sendeski2012IodinatedCM,
  title={Iodinated contrast media cause endothelial damage leading to vasoconstriction of human and rat vasa recta.},
  author={Mauricio M. Sendeski and Anja Bondke Persson and Zhi Zhao Liu and Jonas Felix Busch and Steffen Weikert and Pontus Persson and Stefan Hippenstiel and Andreas Patzak},
  journal={American journal of physiology. Renal physiology},
  year={2012},
  volume={303 12},
  pages={F1592-8}
}
Contrast-induced acute kidney injury is an important clinical event with a worldwide increasing number of cases. Medullary hypoperfusion and hypoxia due to constriction of vasa recta are main factors in the pathophysiology of acute kidney injury. However, the mechanism of contrast media (CM)-induced vessel constriction is not known. We tested the hypothesis… CONTINUE READING