Iodide kinetics and experimental (131)I therapy in a xenotransplanted human sodium-iodide symporter-transfected human follicular thyroid carcinoma cell line.

@article{Smit2002IodideKA,
  title={Iodide kinetics and experimental (131)I therapy in a xenotransplanted human sodium-iodide symporter-transfected human follicular thyroid carcinoma cell line.},
  author={Jan Smit and Janny P. Schr{\"o}der-van der Elst and Marcel Karperien and Ivo Que and Marcel P. M. Stokkel and Daan van der Heide and Johannes Anthonius Romijn},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 3},
  pages={1247-53}
}
Uptake of iodide is a prerequisite for radioiodide therapy in thyroid cancer. However, loss of iodide uptake is frequently observed in metastasized thyroid cancer, which may be explained by diminished expression of the human sodium-iodide symporter (hNIS). We studied whether transfection of hNIS into the hNIS-deficient follicular thyroid carcinoma cell line FTC133 restores the in vivo iodide accumulation in xenografted tumors and their susceptibility to radioiodide therapy. In addition, the… CONTINUE READING

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