Iodide, thyroid and stomach carcinogenesis: evolutionary story of a primitive antioxidant?

  title={Iodide, thyroid and stomach carcinogenesis: evolutionary story of a primitive antioxidant?},
  author={Sebastiano Venturi and Mattia Venturi},
  journal={European journal of endocrinology},
  volume={140 4},
The thyroid gland is, embryogenetically and phylogenetically, derived from the primitive gut, and we may consider the thyroid cells as primitive gastroenteric cells which, during evolution, migrated and specialized in the uptake of iodide and in the storage and elaboration of iodine compounds. The stomach and the thyroid share iodideconcentrating ability and many morphological and functional similarities such as cell polarity and apical microvilli, similar organ-specific antigens and associated… CONTINUE READING
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