Inward rectifiers in the heart: an update on I(K1).

  title={Inward rectifiers in the heart: an update on I(K1).},
  author={Anatoli N. Lopatin and Colin G. Nichols},
  journal={Journal of molecular and cellular cardiology},
  volume={33 4},
The cardiac inward rectifier potassium current (I(K1)), present in all ventricular and atrial myocytes, has been suggested to play a major role in repolarization of the action potential and stabilization of the resting potential. The molecular basis is now ascribed to members of the Kir2 sub-family of inward rectifier K channel genes, and the availability of recombinant expression systems has led to elucidation of the mechanism of inward rectification, as well as additional regulatory… CONTINUE READING

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