Inward rectification by polyamines in mouse Kir2.1 channels: synergy between blocking components.

@article{Xie2003InwardRB,
  title={Inward rectification by polyamines in mouse Kir2.1 channels: synergy between blocking components.},
  author={Lai-hua Xie and Scott A. John and James N. Weiss},
  journal={The Journal of physiology},
  year={2003},
  volume={550 Pt 1},
  pages={67-82}
}
We recently characterized two distinct mechanisms by which the polyamine spermine blocks Kir2.1 channels: (1) by reduction of negative surface charges in the cytoplasmic pore, thereby reducing single-channel conductance, and (2) by direct open channel transmembrane pore block. The extent to which the surface charge reduction component is mediated by passive surface charge screening versus binding of polyamines to these charges, as well as the extent to which the surface charge reduction and… CONTINUE READING
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