Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells.

@article{AndoAkatsuka2012InvolvementsOT,
  title={Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells.},
  author={Yuhko Ando-Akatsuka and Takahiro Shimizu and Tomohiro Numata and Yasunobu Okada},
  journal={Journal of cellular physiology},
  year={2012},
  volume={227 10},
  pages={
          3498-510
        }
}
After osmotic swelling, cell volume is regulated by a process called regulatory volume decrease (RVD). Although actin cytoskeletons are known to play a regulatory role in RVD, it is not clear how actin-binding proteins are involved in the RVD process. In the present study, an involvement of an actin-binding protein, α-actinin-4 (ACTN4), in RVD was examined in human epithelial HEK293T cells. Overexpression of ACTN4 significantly facilitated RVD, whereas siRNA-mediated downregulation of… CONTINUE READING

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