Involvements of Rho-kinase and TGF-beta pathways in aldosterone-induced renal injury.

@article{Sun2006InvolvementsOR,
  title={Involvements of Rho-kinase and TGF-beta pathways in aldosterone-induced renal injury.},
  author={Guang-Ping Sun and Masakazu Kohno and Peng Sheng Guo and Yukiko Nagai and Kayoko Miyata and Yu-Yan Fan and Shoji Kimura and Hideyasu Kiyomoto and Koji Ohmori and De-tian Li and Youichi Abe and Akira Nishiyama},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2006},
  volume={17 8},
  pages={2193-201}
}
Recent studies have suggested a role for aldosterone in the pathogenesis of renal injury. This study investigated the potential contributions of Rho-kinase and TGF-beta pathways to aldosterone-induced renal injury. Rats were uninephrectomized and then treated for 5 wk with 1% NaCl in a drinking solution and one of the following: Vehicle (2% ethanol, subcutaneously; n = 9); aldosterone (0.75 microg/h, subcutaneously; n = 9); or aldosterone + fasudil, a specific Rho-kinase inhibitor (10 mg/kg per… CONTINUE READING
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Involvement of AP-1 on the down regulation of catecholamine synthetic pathway by Rho kinase inhibitor in spontaneously hypertensive rats [Abstract

  • T Kumai, N Matsumoto, Y Takeda, S Nakaya, S Kobayashi
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