Involvement of yeast YOL151W/GRE2 in ergosterol metabolism.

  title={Involvement of yeast YOL151W/GRE2 in ergosterol metabolism.},
  author={Jonas Warringer and Anders Blomberg},
  volume={23 5},
The Saccharomyces cerevisiae gene YOL151W/GRE2 is widely used as a model gene in studies on yeast regulatory responses to osmotic and oxidative stress. Nevertheless, information concerning the physiological role of this enzyme, a distant homologue of mammalian 3-beta-hydroxysteroid dehydrogenases, is scarce. Combining quantitative phenotypic profiling and protein expression analysis studies, we here report the involvement of yeast Gre2p in ergosterol metabolism. Growth was significantly and… CONTINUE READING


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