Involvement of upregulation of DEPDC1 (DEP domain containing 1) in bladder carcinogenesis

@article{Kanehira2007InvolvementOU,
  title={Involvement of upregulation of DEPDC1 (DEP domain containing 1) in bladder carcinogenesis},
  author={Makiko Kanehira and Yui Harada and Ryo Takata and Taro Shuin and Tohru Miki and Tomoaki Fujioka and Yusuke Nakamura and Toyomasa Katagiri},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={6448-6455}
}
In an attempt to disclose mechanisms of bladder carcinogenesis and discover novel target molecules for development of treatment, we applied a cDNA microarray to screen genes that were significantly transactivated in bladder cancer cells. Among the upregulated genes, we here focused on a novel gene, (DEPDC1) DEP domain containing 1, whose overexpression was confirmed by northern blot and immunohistochemical analyses. Immunocytochemical staining analysis detected strong staining of endogenous… CONTINUE READING

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