Involvement of tumor necrosis factor-alpha in the pathogenesis of activated macrophage-mediated hepatitis in mice.

@article{Nagakawa1990InvolvementOT,
  title={Involvement of tumor necrosis factor-alpha in the pathogenesis of activated macrophage-mediated hepatitis in mice.},
  author={J. Nagakawa and Ieharu Hishinuma and Kiichi Hirota and K Miyamoto and T. Yamanaka and Kazuo Tsukidate and K. Katayama and Isao Yamatsu},
  journal={Gastroenterology},
  year={1990},
  volume={99 3},
  pages={758-65}
}
The possible involvement of tumor necrosis factor-alpha in the pathogenesis of an experimentally induced hepatitis was investigated. Balb/c mice were primed with Propionibacterium acnes to induce the infiltration of mononuclear cells into the liver. Immunohistochemical study showed that most of the accumulated mononuclear cells at 7 days were Mac-2 positive, suggesting that they were activated macrophages. An injection of lipopolysaccharide resulted in massive hepatic necrosis and high… CONTINUE READING