Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans.

@article{Yamashiro2006InvolvementOT,
  title={Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans.},
  author={Wakaba Yamashiro and Kazuya Maeda and Masakazu Hirouchi and Yasuhisa Adachi and Zhuohan Hu and Yuichi Sugiyama},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2006},
  volume={34 7},
  pages={1247-54}
}
Valsartan is a highly selective angiotensin II AT1-receptor antagonist for the treatment of hypertension. Valsartan is mainly excreted into the bile in unchanged form. Because valsartan has an anionic carboxyl group, we hypothesized that a series of organic anion transporters could be involved in its hepatic clearance. In this study, to identify transporters that mediate the hepatic uptake and biliary excretion of valsartan and estimate the contribution of each transporter to the overall… CONTINUE READING
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