Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation.

@article{Keeble2005InvolvementOT,
  title={Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation.},
  author={Julie Elizabeth Keeble and Fiona Russell and Bradley Curtis and Anna Speisman Starr and Erika Pint{\'e}r and Susan Diana Brain},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 10},
  pages={3248-56}
}
OBJECTIVE To investigate the endogenous involvement of transient receptor potential vanilloid 1 (TRPV1) in a model of knee joint inflammation in the mouse. METHODS Following characterization of wild-type (WT) and TRPV1-knockout mice, inflammation was induced via intraarticular (IA) injection of Freund's complete adjuvant (CFA). Knee swelling was assessed as diameter, and inflammatory heat hyperalgesia was determined using the Hargreaves technique, for up to 3 weeks. At 18 hours, acute… CONTINUE READING

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