Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis.

@article{Balloy2005InvolvementOT,
  title={Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis.},
  author={Viviane Balloy and Mustapha Si-Tahar and Osamu Takeuchi and Bruno Philippe and M. A. Nahori and Myriam Tanguy and Michel Ren{\'e} Huerre and Shizuo Akira and J. P. Latg{\'e} and Michel Chignard},
  journal={Infection and immunity},
  year={2005},
  volume={73 9},
  pages={5420-5}
}
Aspergillus fumigatus, an opportunistic fungal pathogen, causes severe and usually fatal invasive pulmonary aspergillosis in immunocompromised hosts. Interestingly, Drosophila cells lacking the Toll protein are prone to A. fumigatus infection. In the current study, we looked for the involvement of Toll-like receptor 2 (TLR2) in the recognition of A. fumigatus by analyzing the in vivo and ex vivo responses of immunocompromised TLR2(-/-) and TLR2(+/+) mice to this fungus. Upon intratracheal… CONTINUE READING