Involvement of thymosin beta 4 and endoproteinase Asp-N in the biosynthesis of the tetrapeptide AcSerAspLysPro a regulator of the hematopoietic system.

@article{Grillon1990InvolvementOT,
  title={Involvement of thymosin beta 4 and endoproteinase Asp-N in the biosynthesis of the tetrapeptide AcSerAspLysPro a regulator of the hematopoietic system.},
  author={Catherine Grillon and Kathrin Rieger and Johanna Bakala and Dominique Schott and Jean Louis Morgat and Ewald Hannappel and Wolfgang Prof Dr Voelter and Maryse Lenfant},
  journal={FEBS letters},
  year={1990},
  volume={274 1-2},
  pages={
          30-4
        }
}
It is shown that AcSDKP a new regulator of the hematopoietic system can be generated from thymosin beta 4 by a one-step enzymatic cleavage in vitro and in vivo. AcSDKP and T beta 4 were both detected in bone marrow cells (BMC). Incubation of [3H]T beta 4 with either intact or lysed BMC led to the formation of [3H]AcSDKP whereas the labelled tetrapeptide was not degraded under these conditions. Model enzymatic degradation of T beta 4 carried out with bacterial enzymes suggests that a mammalian… CONTINUE READING
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