Involvement of three meningococcal surface-exposed proteins, the heparin-binding protein NhbA, the α-peptide of IgA protease and the autotransporter protease NalP, in initiation of biofilm formation.

@article{Arenas2013InvolvementOT,
  title={Involvement of three meningococcal surface-exposed proteins, the heparin-binding protein NhbA, the α-peptide of IgA protease and the autotransporter protease NalP, in initiation of biofilm formation.},
  author={J. Mateo Arenas and Reindert Nijland and Francisco Jim{\'e}nez Rodr{\'i}guez and Tom N. P. Bosma and Jan P Tommassen},
  journal={Molecular microbiology},
  year={2013},
  volume={87 2},
  pages={254-68}
}
Neisseria meningitidis is a common and usually harmless inhabitant of the mucosa of the human nasopharynx, which, in rare cases, can cross the epithelial barrier and cause meningitis and sepsis. Biofilm formation favours the colonization of the host and the subsequent carrier state. Two different strategies of biofilm formation, either dependent or independent on extracellular DNA (eDNA), have been described for meningococcal strains. Here, we demonstrate that the autotransporter protease NalP… CONTINUE READING
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