Involvement of thioredoxin-interacting protein (TXNIP) in glucocorticoid-mediated beta cell death

@article{Reich2011InvolvementOT,
  title={Involvement of thioredoxin-interacting protein (TXNIP) in glucocorticoid-mediated beta cell death},
  author={E. -P. Reich and A. Tamary and Ronit Vogt Sionov and Danielle Melloul},
  journal={Diabetologia},
  year={2011},
  volume={55},
  pages={1048-1057}
}
Glucocorticoid hormones (GCs) are widely used to treat a variety of inflammatory and immune diseases. However, their long-term administration is associated with adverse metabolic effects, including glucose intolerance and diabetes. Our objective was to elucidate the mechanisms by which GCs affect beta cell survival with a specific emphasis on the role of the thioredoxin-interacting protein (TXNIP) in beta cell apoptosis. Human and mouse islets, together with MIN6 beta cells, were exposed to… CONTINUE READING