Involvement of the vacuolar H(+)-ATPase in animal virus entry.

  title={Involvement of the vacuolar H(+)-ATPase in animal virus entry.},
  author={Luis Perez and Luis Carrasco},
  journal={The Journal of general virology},
  volume={75 ( Pt 10)},
Semliki Forest virus (SFV) enters cells by receptor-mediated endocytosis, followed by acidification of endosomes by the action of the vacuolar H(+)-ATPase. Fusion of the viral and the endosomal membrane delivers the viral genome to the cytoplasm. Direct blockade of the vacuolar H(+)-ATPase by the selective inhibitor bafilomycin A1 (BFLA1) prevented the infection of cells by SFV, if the compound was present during the first minutes of infection. Attachment and penetration of virus particles were… CONTINUE READING


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