Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.

@article{Ikeda2007InvolvementOT,
  title={Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.},
  author={Fumiyo Ikeda and Christina Maria Hecker and Alexis Rozenknop and Rolf Dietrich Nordmeier and Vladimir Aleksandrovich Rogov and Kay Hofmann and Shizuo Akira and Volker D{\"o}tsch and Ivan Dikic},
  journal={The EMBO journal},
  year={2007},
  volume={26 14},
  pages={3451-62}
}
TANK-binding kinase 1 (TBK1/NAK/T2K) and I-kappaB Kinase (IKK-i/IKK-epsilon) play important roles in the regulation of interferon (IFN)-inducible genes during the immune response to bacterial and viral infections. Cell stimulation with ssRNA virus, dsDNA virus or gram-negative bacteria leads to activation of TBK1 or IKK-i, which in turn phosphorylates the… CONTINUE READING