Involvement of the tyrosine kinase fer in cell adhesion.

  title={Involvement of the tyrosine kinase fer in cell adhesion.},
  author={Roberto R. Rosato and Jacqueline M. Veltmaat and John Groffen and Nora Heisterkamp},
  journal={Molecular and cellular biology},
  volume={18 10},
The Fer protein belongs to the fes/fps family of nontransmembrane receptor tyrosine kinases. Lack of success in attempts to establish a permanent cell line overexpressing it at significant levels suggested a strong negative selection against too much Fer protein and pointed to a critical cellular function for Fer. Using a tetracycline-regulatable expression system, overexpression of Fer in embryonic fibroblasts was shown to evoke a massive rounding up, and the subsequent detachment of the cells… CONTINUE READING
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