Involvement of the "tethered-ligand" receptor in thrombin inhibition of platelet adenylate cyclase.

Abstract

Thrombin is thought to activate platelets through multiple signaling pathways. Recently a new thrombin receptor was identified (Vu et al., Cell 64:1057-1068, 1991) that recognizes alpha-thrombin's anion-binding exosite. Thrombin cleaves this receptor generating a new N-terminal ("tethered-ligand") that activates the receptor. We report here that this… (More)

Topics

Cite this paper

@article{Seiler1992InvolvementOT, title={Involvement of the "tethered-ligand" receptor in thrombin inhibition of platelet adenylate cyclase.}, author={Steve M Seiler and Inge M. Michel and John W. Fenton}, journal={Biochemical and biophysical research communications}, year={1992}, volume={182 3}, pages={1296-302} }