Involvement of the sympathetic nervous system in the cardiovascular effects of ACTH-(1-24) during hemorrhagic shock in rats

@article{Guarini1988InvolvementOT,
  title={Involvement of the sympathetic nervous system in the cardiovascular effects of ACTH-(1-24) during hemorrhagic shock in rats},
  author={Salvatore Guarini and William Ferrari and Alfio Bertolini},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1988},
  volume={337},
  pages={556-560}
}
In urethane-anesthetized rats, removal of about 50% of the total blood volume over a period of 25 – 30 min caused hypovolemic shock, with extreme hypotension (MAP = 18–25 mmHg and death of all animals within 22±5 min. The i.v. injection of ACTH-(1-24) in the dose range of 40–160 μg/kg induced a sustained, dose-dependent, and, at the highest dose used, an almost complete recovery of blood pressure, and 100% survival, at least for 2 h after treatment. The effect of ACTH-(1–24) was completely… CONTINUE READING

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