Involvement of the sugar moiety in the inhibitory action of the cardiac glycosides on the palytoxin-induced responses in vascular smooth muscles.

@article{Ozaki1984InvolvementOT,
  title={Involvement of the sugar moiety in the inhibitory action of the cardiac glycosides on the palytoxin-induced responses in vascular smooth muscles.},
  author={Hiroshi Ozaki and Hiromi Nagase and Norimoto Urakawa},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1984},
  volume={231 1},
  pages={153-8}
}
The effects of ouabain and other cardiotonic steroids were examined to investigate whether changes in Na,K-adenosine triphosphatase (ATPase) activity modified the actions of palytoxin (PTX) in rabbit aortic vascular smooth muscle. The effects of these agents on rabbit aorta were compared with those on rat aorta, as it is known that the concentration of cardiac glycosides required to inhibit Na,K-ATPase of rat aorta is markedly higher than that of other species. PTX induced contraction in rabbit… CONTINUE READING
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