Involvement of the small GTPase rho in integrin-mediated activation of mitogen-activated protein kinase.

@article{Renshaw1996InvolvementOT,
  title={Involvement of the small GTPase rho in integrin-mediated activation of mitogen-activated protein kinase.},
  author={Mark W. Renshaw and Deniz Toksoz and Martin A Schwartz},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 36},
  pages={21691-4}
}
Engagement and clustering of integrins triggers a number of intracellular signaling events, including activation of the mitogen-activated protein (MAP) kinases Erk1 and Erk2. To investigate the mechanism by which integrins mediate the activation of MAP kinases upon binding of NIH 3T3 cells to fibronectin, we assessed the effects of both inhibiting and activating the small GTPase Rho. We observed that inhibition of Rho by the Rho-specific inhibitor C3 exoenzyme or by a dominant negative Rho A… CONTINUE READING

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