Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length.

@article{Lustig1990InvolvementOT,
  title={Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length.},
  author={Arthur J. Lustig and Sherry Kurtz and David Shore},
  journal={Science},
  year={1990},
  volume={250 4980},
  pages={549-53}
}
The yeast protein RAP1, initially described as a transcriptional regulator, binds in vitro to sequences found in a number of seemingly unrelated genomic loci. These include the silencers at the transcriptionally repressed mating-type genes, the promoters of many genes important for cell growth, and the poly[(cytosine)1-3 adenine] [poly(C1-3A)] repeats of telomeres. Because RAP1 binds in vitro to the poly(C1-3A) repeats of telomeres, it has been suggested that RAP1 may be involved in telomere… CONTINUE READING

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